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Emphysema |
| Definition: |
| A lung disease which involves damage to the air sacs (alveoli) in the lungs. The air sacs are unable to completely deflate (hyperinflation) and are therefore unable to fill with fresh air to ensure adequate oxygen supply to the body. |
| Causes, incidence, and risk factors: |
| Cigarette smoking is the most common cause of emphysema. Tobacco smoke and other pollutants are thought to cause the release of chemicals from within the lungs that damage the walls of the air sacs. This damage becomes worse over time, affecting the exchange of oxygen and carbon dioxide in the lungs. A naturally-occurring substance in the lungs called alpha-1 antitrypsin may protect against this damage. People with alpha-1 antitrypsin deficiency are at an increased risk for this disease. |
| Symptoms: |
Additional symptoms that may be associated with this disease:
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| Signs and tests: |
| A physical examination may show decreased breath sounds, wheezing, and/or prolonged exhalation (exhalation takes more than twice as long as inspiration). There may be an increased front-to-back diameter of the chest (barrel shaped chest). There may be signs of chronically insufficient oxygen levels in the blood. These tests help confirm the diagnosis: This disease may also alter the results of the following tests:
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| Treatment: |
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Smoking cessation is the most important and effective treatment. Only quitting smoking can stop the progression of lung damage once it has started. Medications used to improve breathing include bronchodilators (hand-held inhaler or nebulizer), diuretics, and corticosteroids. Antibiotics may be prescribed when respiratory infections occur. Influenza (flu) vaccines and Pneumovax are recommended for people with emphysema. EXPERIMENTAL THERAPY: An experimental surgery, called lung reduction, is currently being studied in patients with severe emphysema. Lung reduction surgery removes the damaged portions of the lung, which allows the normal portions of the lung to expand more fully and take advantage of increased aeration. It is not yet known whether this surgery is effective. |
| Support Groups: |
| Contact the American Lung Association for a support group near you. |
| Expectations (prognosis): |
| The outcome is better for patients with less damage to the lung. However, patients with extensive lung damage may live for many years so predicting prognosis is difficult. Death may occur from respiratory failure, pneumonia, or other complications. |
| Complications: |
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| Calling your health care provider: |
| Call your health care provider if symptoms of emphysema develop. If you know you have emphysema, call your health care provider if breathing difficulty, cough, sputum production or fever develops or changes. |
| Prevention: |
| Avoiding smoking -- or quitting if you do smoke -- can greatly decrease risk for this disease. |
Reviewed By: Steven Kawut, M.D., Pulmonary, Allergy and Critical Care Medicine, University of Pennsylvania Medical Center, Philadelphia, PA. Review provided by VeriMed Healthcare Network.
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