Lambert-Eaton syndrome (myasthenic syndrome) is a disorder with symptoms very similar to those of myasthenia gravis. There is muscle weakness associated with disturbed communication between nerves and muscles.

In myasthenia gravis, the neurotransmitter acetylcholine (the chemical that transmits impulses between nerves and muscles) is blocked by antibodies to its receptor. In Lambert-Eaton syndrome, however, the signal distortion is caused by an insufficient release of neurotransmitter by the nerve cell. As muscle contraction is continued, the amount of neurotransmitter may build up in sufficient quantities and result in increased strength.

The disorder may be associated with small-cell carcinoma of the lung and other malignancies as a paraneoplastic syndrome or with autoimmune disorders.

• Weakness/paralysis that varies in amount
  • Drooping head
  • Difficulty climbing stairs
  • Difficulty lifting objects
  • Need to use hands to arise from sitting or lying positions
  • Difficulty talking
  • Difficulty chewing
• Swallowing difficulty, gagging or choking
• Vision changes
  • Blurry vision
  • Difficulty maintaining steady gaze

Additional symptoms that may be associated with this disease:

• Blood pressure abnormalities
• Dizziness upon standing
• Dry mouth

The primary goal of treatment is to identify and treat any tumors or other underlying disorders. Plasmapheresis, where blood plasma is removed and replaced with fluid, may improve symptoms.

Prednisone or other medications that suppress the immune response may improve symptoms in some cases. Medications can also include anticholinesterase medications such as Neostigmine or Pyridostigmine.

• Difficulty breathing
• Difficulty swallowing