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| Pronunciation |
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 (DOKS
e
pin) |
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| Brand Names |
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| Sinequan® Oral; Zonalon® Topical
Cream |
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| Foreign Brand
Names |
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| Apo-Doxepin® (Canada); Novo-Doxepin
(Canada); Triadapin®
(Canada) |
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| Therapeutic
Categories |
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Antidepressant, Tricyclic (Tertiary Amine); Topical Skin
Product |
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| Reasons not to take this
medicine |
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- If you have an allergy to doxepin or any other part of the medicine.
If you are allergic to another medicine used for depression you may also be
allergic to this one. Talk with healthcare provider.
- If you have had a recent heart attack or have difficulty urinating.
- If you have taken a monoamine oxidase inhibitor (isocarboxazid,
phenelzine, selegiline) in the past 14
days.
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| What is this medicine used
for? |
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|
- This medicine is used for the treatment of depression, anxiety
disorders, obsessive and compulsive symptoms, panic disorder, eating disorders,
and chronic pain conditions.
- It is also used to prevent migraine headaches and bedwetting in
children.
- The cream is used to treat
itching.
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| How does it work? |
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- Doxepin increases chemicals in the brain. Sleep and appetite may
improve quickly. Other depressive symptoms may take up to 4-6 weeks to improve.
It blocks the cause of the itch.
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| How is it best taken? |
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- Oral:
- Take with or without food. Take with food if this medicine causes an
upset stomach.
- Do not suddenly stop using this medicine if you have been taking it
for a long time. Medicine should be slowly decreased.
- May take at bedtime if it causes too much drowsiness.
- A liquid (concentrate) is available if you cannot swallow pills. Those
who have feeding tubes can also use the liquid. Flush the feeding tube before
and after medicine is given.
- Skin:
- Do not take by mouth. For skin only. Keep out of mouth, nose, and eyes
(may burn).
- Use a small amount over the area affected as a light film. Run in
gently.
- Do not put coverings (bandages, dressings, make-up) over the area
unless told to do so by healthcare
provider.
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| What do I do if I miss a
dose? |
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- Oral:
- Take a missed dose as soon as possible.
- If it is almost time for the next dose, skip the missed one. Return to
your regular schedule.
- Do not take a double dose or extra doses.
- Topical:
- This medicine can be used on an as needed
basis.
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| What are the precautions when
taking this
medicine? |
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- If you are 65 or older, you have more side effects. Feeling sleepy,
dizzy, or lightheaded could be dangerous. There are other choices if this
medicine is too strong for you.
- You may not be alert. Avoid driving, doing other tasks or activities
until you see how this medicine affects you.
- Avoid alcohol (includes wine, beer, and liquor) and other medicines
and herbs that slow your actions and reactions. This includes sedatives,
tranquilizers, mood stabilizers, or pain medicine. Talk with healthcare
provider.
- Make sure to get good dental care. You may have a higher risk for
cavities.
- Tell healthcare provider if you are allergic to any medicine. Make
sure to tell about the allergy and how it affected you. This includes telling
about rash; hives; itching; shortness of breath; wheezing; cough; swelling of
face, lips, tongue, throat; or any other symptoms involved.
- Tell healthcare provider if you are pregnant or plan on getting
pregnant.
- Tell healthcare provider if you are
breast-feeding.
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| What are the common side effects
of this
medicine? |
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- Feeling sleepy, lightheaded, or having blurred vision. Avoid driving,
doing other tasks or activities that require you to be alert until you see how
this medicine affects you.
- Dizziness is common. Rise slowly over several minutes from sitting or
lying position. Be careful climbing stairs.
- Dry mouth. Frequent mouth care, sucking hard candy, or chewing gum may
help.
- Constipation. More liquids, regular exercise, or a fiber-containing
diet may help. Talk with healthcare provider about a stool softener or laxative.
- Unable to pass urine. Go to the bathroom before taking medicine. Talk
with healthcare provider if it becomes a
problem.
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| What should I monitor? |
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- Follow up with healthcare
provider.
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| Reasons to call healthcare
provider
immediately |
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- Signs of a life-threatening reaction. These include wheezing;
tightness in the chest; fever; itching; bad cough; blue skin color; fits;
swelling of face, lips, tongue, or throat.
- Changes in thinking clearly and logically.
- Too tired or sleepy.
- Passing out, fainting, dizziness, or lightheadedness.
- Any rash.
- No improvement in condition or feeling
worse.
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| How should I store this
medicine? |
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- Store in a tight container at room
temperature.
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| General statements |
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- Do not share your medicine with others and do not take anyone else's
medicine.
- Keep all medicine out of the reach of children and pets.
- Keep a list of all your medicines (prescription, herbal/supplements,
vitamins, over-the-counter) with you. Give this list to healthcare provider
(doctor, nurse, pharmacist, physician assistant).
- Talk with healthcare provider before starting any new medicine,
including over-the-counter or natural products (herbs,
vitamins).
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