Drugs >  Estradiol Cypionate and ...
Estradiol Cypionate and Medroxyprogesterone Acetate
Brand Names
Therapeutic Categories
What key warnings should I know about before taking this medicine?
Reasons not to take this medicine
What is this medicine used for?
How does it work?
How is it best taken?
What do I do if I miss a dose?
What are the precautions when taking this medicine?
What are the common side effects of this medicine?
What should I monitor?
Reasons to call healthcare provider immediately
How should I store this medicine?
General statements

Brand Names
Lunelle™

Therapeutic Categories
Contraceptive

What key warnings should I know about before taking this medicine?

  • This medicine does not protect against HIV disease and other sexually transmitted diseases.


Reasons not to take this medicine

  • If you have an allergy to estrogens, medroxyprogesterone, or any other part of the medicine.
  • If you have any of the following conditions: Unexplained vaginal bleeding, any history of blood clots, severe high blood pressure, heart problems related to a heart valve, history of stroke or disease of the arteries in the brain, disease of the arteries in the heart, breast cancer, cancer whose growth is increased by estrogen, liver disease, specific type of headache, diabetes that has affected the blood vessels.
  • If you are older than 35 years of age and smoke 15 or more cigarettes a day.
  • If you are pregnant or think you may be pregnant.
  • If you turned yellow (jaundice) or had severe itching when pregnant.
  • If you turned yellow (jaundice) when taking birth control pills.
  • If you have had a baby less than 4 weeks ago and are not breast-feeding.
  • If you have had a baby less than 6 weeks ago and are breast-feeding.


What is this medicine used for?

  • This medicine is used to prevent you from getting pregnant.


How does it work?

  • Estradiol and medroxyprogesterone prevent the eggs from maturing and may make getting pregnant more difficult.


How is it best taken?

  • This medicine is given in the healthcare provider's office once a month as a shot. The first shot is giving within the first 5 days of your period.
  • It must be given once every 28 to 30 days. If you cannot get your next shot on time contact healthcare provider for an earlier one.


What do I do if I miss a dose?

  • Get to your healthcare provider's office for the shot as soon as possible.
  • If more than 33 days have passed since your last shot then you need a pregnancy test first.


What are the precautions when taking this medicine?

  • Do not smoke. Smoking may increase the risk of heart disease and cause circulation problems when used with this medicine. If you are over 35 years of age the risk increases.
  • Limit alcohol intake (includes wine, beer, and liquor). Routine use may increase risk of breast cancer.
  • Side effects may increase in people with high blood pressure, high triglyceride levels in the blood, or diabetes. Talk with healthcare provider.
  • Use caution if you have gallbladder disease. Talk with healthcare provider.
  • Use caution if you have a weakened heart or any problems with extra fluid. Talk with healthcare provider.
  • Tell surgeons about this medicine. If you are having surgery you may need to stop the medicine. This will reduce the risk of developing blood clots. If you are unable to get out of bed while recuperating from surgery then stay off the medicine. Talk with healthcare provider.
  • Check medicines with healthcare provider. This medicine may not mix well with other medicines.
  • Do not use St. John's wort. You could get pregnant if you use with birth control.
  • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, throat; or any other symptoms involved.
  • This medicine does not protect against HIV disease and other sexually transmitted diseases.
  • Do not use in pregnancy.
  • This birth control may not work any longer if you have not had a shot in 33 days. Use another form of birth control.
  • Do not use if you are breast-feeding and your baby is less than 6 weeks old.
  • If you want to get pregnant then stop your monthly shots. Most women begin to produce eggs again in about 2 to 3 months after their last shot. Be sure to start folic acid supplements before trying to get pregnant.


What are the common side effects of this medicine?

  • Weight gain.
  • Emotional ups and downs.
  • Swelling and bloating.
  • Breast enlargement and tenderness.
  • Nausea. Small frequent meals, frequent mouth care, sucking hard candy, or chewing gum may help.
  • Headache. Mild pain medicine may help.
  • Vaginal bleeding (breakthrough bleeding, spotting) may occur.


What should I monitor?

  • If you are a contact lens wearer, look for changes in comfort of lens. If lenses become uncomfortable, call healthcare provider.
  • If shot is not given within 33 days, a pregnancy test must be done before you get another shot.
  • Periodic breast and gynecologic exams.
  • Check lipid (triglyceride) panel if you have a history of high triglyceride levels in your blood. Talk with healthcare provider.
  • Follow up with healthcare provider every month for next shot.


Reasons to call healthcare provider immediately

  • Signs of a life-threatening reaction. These include wheezing; tightness in the chest; fever; itching; bad cough; blue skin color; fits; swelling of face, lips, tongue, throat.
  • Change in eyesight or vision loss.
  • Sharp chest pain or pressure.
  • Leg pain or sudden shortness of breath.
  • Severe headaches.
  • Change in speech, weakness or numbness on one side of body.
  • Nausea, vomiting, belly pain, feeling tired, dark urine, yellow eyes or skin, not hungry.
  • Breast lump.
  • Unusual vaginal bleeding. This includes lots of bleeding, spotting, or bleeding between cycles.
  • Any rash.
  • You are pregnant.


How should I store this medicine?

  • This medicine will be stored in your healthcare provider's office.


General statements

  • Do not share your medicine with others and do not take anyone else's medicine.
  • Keep all medicine out of the reach of children and pets.
  • Keep a list of all your medicines (prescription, herbal/supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, pharmacist, physician assistant).
  • Talk with healthcare provider before starting any new medicine, including over-the-counter or natural products (herbs, vitamins).


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