Drugs >  Metronidazole
Metronidazole
Pronunciation
Brand Names
Foreign Brand Names
Therapeutic Categories
What key warnings should I know about before taking this medicine?
Reasons not to take this medicine
What is this medicine used for?
How does it work?
How is it best taken?
What do I do if I miss a dose?
What are the precautions when taking this medicine?
What are the common side effects of this medicine?
What should I monitor?
Reasons to call healthcare provider immediately
How should I store this medicine?
General statements

Pronunciation
(me troe NI da zole)

Brand Names
Flagyl®; Flagyl ER®; MetroCream®; MetroGel® Topical; MetroGel®-Vaginal; Metro I.V.® Injection; MetroLotion®; Noritate™ Cream; Protostat® Oral

Foreign Brand Names
Ameblin (Mexico); Apo-Metronidazole® (Canada); Flagenase® (Mexico); Milezzol (Mexico); Novo-Nidazol (Canada); Otrozol (Mexico); Vatrix-S® (Mexico); Vertisal (Mexico)

Therapeutic Categories
Amebicide; Antibiotic, Topical; Antibiotic, Miscellaneous; Antiprotozoal

What key warnings should I know about before taking this medicine?

  • Talk with healthcare provider.


Reasons not to take this medicine

  • If you have an allergy to metronidazole or any other part of the medicine.
  • If you are in your first 12 weeks of pregnancy.


What is this medicine used for?

  • This medicine, when taken by mouth, is used to treat a variety of infections.
  • As a skin cream or gel it is used to treat acne rosacea. It may take 3-9 weeks to see full benefit.
  • As a gel, it is used to treat vaginal infections.


How does it work?

  • Metronidazole causes death of the cells causing the infection.


How is it best taken?

  • To gain the most benefit, do not miss doses.
  • Take entire prescription as directed even if feeling better.
  • Oral:
    • Take with or without food. Take with food if this medicine causes an upset stomach.
    • Do not take antacids with this medicine.
  • Skin:
    • Do not take by mouth. For skin only. Keep out of mouth, nose, and eyes (may burn).
    • Wash your hands before and after use.
    • Clean affected area before use.
    • Use a small amount over the area affected as a light film. Rub in gently.
  • Vaginal:
    • Use gel vaginally only.
    • Do not have sexual intercourse while using this medicine.


What do I do if I miss a dose?

  • Take a missed dose as soon as possible.
  • If it is almost time for the next dose, skip the missed one. Return to your regular schedule.
  • Do not take a double dose or extra doses.


What are the precautions when taking this medicine?

  • Avoid all alcohol (includes wine, beer, and liquor). Can cause a bad reaction.
  • This could include flushing, headache, nausea, vomiting, sweating, or rapid heartbeat. Do not take alcohol for at least 24 hours after the last dose.
  • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, throat; or any other symptoms involved.
  • Do not use in the first trimester of pregnancy.
  • Birth control pills may not work. Use another form of birth control while on this medicine.
  • Do not use if you are breast-feeding.
  • Oral:
  • Tell healthcare provider if on phenytoin, phenobarbital, warfarin, lithium, or cimetidine.


What are the common side effects of this medicine?

  • Lightheadedness or dizziness. Use caution when driving, doing other tasks or activities that require you to be alert until you see how this medicine affects you.
  • Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard candy, or chewing gum may help.
  • Diarrhea. Yogurt, Bifidobacterium bifidum , or Lactobacillus acidophilus may help. These products are available at health food stores or in some pharmacies.
  • Headache. Mild pain medicine may help.
  • Not hungry or change in taste. Food may have a metal-like taste.
  • Can change urine to black or dark brown.
  • Skin:
    • Redness, dryness, burning, or irritation.


What should I monitor?

  • Condition being treated. Is it better, worse, or about the same.
  • Oral:
    • Watch for change in temperature or worsening of infection if you are being treated for an active infection.
    • If on warfarin, get INR checked within 1 week.


Reasons to call healthcare provider immediately

  • Signs of a life-threatening reaction. These include wheezing; tightness in the chest; fever; itching; bad cough; blue skin color; fits; swelling of face, lips, tongue, throat.
  • Numbness or pain of the hands or feet.
  • Any rash.
  • Worsening of condition or feeling worse.


How should I store this medicine?

  • Store in a tight container at room temperature.


General statements

  • Do not share your medicine with others and do not take anyone else's medicine.
  • Keep all medicine out of the reach of children and pets.
  • Keep a list of all your medicines (prescription, herbal/supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, pharmacist, physician assistant).
  • Talk with healthcare provider before starting any new medicine, including over-the-counter or natural products (herbs, vitamins).


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