|
| Pronunciation |
|
 (ni
TIS i
known) |
|
|
| Brand Names |
|
| Orfadin® |
|
|
| Therapeutic
Categories |
|
|
4-Hydroxyphenylpyruvate Dioxygenase Inhibitor |
|
|
| What key warnings should I know
about before taking this
medicine? |
|
|
Nitisinone must be used with a special diet that is low in tyrosine and
phenylalanine. |
|
|
| Reasons not to take this
medicine |
|
|
If you have an allergy to nitisinone or any other part of this
medicine.
Tell healthcare provider if you are allergic to any medicine. Make
sure to tell about the allergy and how it affected you. This includes telling
about rash; hives; itching; shortness of breath; wheezing; cough; swelling of
face, lips, tongue, or throat; or any other symptoms
involved. |
|
|
| What is this medicine used
for? |
|
|
This medicine is used to treat hereditary tyrosinemia type 1
(HT-1). |
|
|
| How does it work? |
|
|
Nitisinone prevents the breakdown of tyrosine. In people with HT-1,
harmful chemicals are formed from tyrosine. |
|
|
| How is it best taken? |
|
|
To gain the most benefit, do not miss doses.
Take this medicine 1 hour before breakfast and dinner.
Swallow capsule whole. Do not chew, break, or crush.
Capsules can be opened and contents mixed with food or liquid.
Follow diet plan as recommended by healthcare
provider. |
|
|
| What do I do if I miss a
dose? |
|
|
Take a missed dose as soon as possible.
If it is almost time for the next dose, skip the missed dose and
return to your regular schedule.
Do not take a double dose or extra doses.
Do not change dose or stop medicine. Talk with healthcare
provider. |
|
|
| What are the precautions when
taking this
medicine? |
|
|
Check medicines with healthcare provider. This medicine may not mix
well with other medicines.
Tell healthcare provider if you are pregnant or plan on getting
pregnant.
Tell healthcare provider if you are
breast-feeding. |
|
|
| What are the common side effects
of this
medicine? |
|
|
Hair loss.
Skin irritation.
Low platelet and white blood cell counts can rarely
occur. |
|
|
| What should I monitor? |
|
|
Change in condition being treated. Is it better, worse, or about the
same?
Dietary intake of tyrosine and phenylalanine.
Check blood work regularly. Talk with healthcare provider.
Follow up with healthcare provider. |
|
|
| Reasons to call healthcare
provider
immediately |
|
|
If you suspect an overdose, call your local poison control center
immediately or dial 911.
Signs of a life-threatening reaction. These include wheezing; chest
tightness; fever; itching; bad cough; blue skin color; fits; or swelling of
face, lips, tongue, or throat.
Change in skin on hands or feet.
Sudden change in vision, eye pain or irritation.
Any rash. |
|
|
| How should I store this
medicine? |
|
|
Store in a refrigerator.
Protect from moisture. Do not store in a bathroom or
kitchen. |
|
|
| General statements |
|
|
Do not share your medicine with others and do not take anyone else's
medicine.
Keep all medicine out of the reach of children and pets.
Keep a list of all your medicines (prescription, natural products,
supplements, vitamins, over-the-counter) with you. Give this list to healthcare
provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
Talk with healthcare provider before starting any new medicine,
including over-the-counter, natural products, or
vitamins. |
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Copyright © 1978-2001 Lexi-Comp Inc. All Rights Reserved
|
