| Depletions > Osteoporosis Medications, ... |  |
| Osteoporosis Medications | ||
| Bisphosphonate Derivatives | ||
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| Depletions | ||
| Calcium | ||
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Osteoporosis (bone loss) is the primary disease associated with long-term calcium deficiency; it may be associated with bone pain and spinal deformity. Depleted levels can also cause muscle cramps, irregular heartbeat, and depression. | ||
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| Phosphorus | ||
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Although phosphorus deficiency is rare, long-term low levels are associated with muscle weakness, bone pain, mental confusion, loss of appetite, anemia, increased susceptibility to infection, respiratory difficulties, seizures, and even death. | ||
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| Editorial Note | ||
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| Supporting Research | ||
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Adami S. Bisphosphonates in prostate carcinoma. Cancer. 1997;80(8 Suppl):1674-1679. Cashman K, Flynn A. Optimal nutrition: calcium, magnesium and phosphorus. Proc Nutr Soc. 1999;58:477-487. Covington T, ed. Nonprescription Drug Therapy Guiding Patient Self-Care. St Louis, MO: Facts and Comparisons; 1999:467-545. O'Doherty DP, Gertz BJ, Tindale W, et al. Effects of five daily 1 h infusions of alendronate on Paget's disease of bone. J Bone Miner Res. 1992;7(1):81-87. Physicians' Desk Reference. 52nd ed. Montvale, NJ: Medical Economics Company; 1998. Potts JT. Diseases of the parathyroid gland and other hyper- and hypocalcemic disorders. In: Fauci AS, Braunwald E, Isselbacher KJ, et al, eds. Harrison's Principles of Internal Medicine. 14th ed. New York: McGraw-Hill Companies Health Professional Division; 1998:2241. | ||
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| Review Date: October 2000 | ||
| Reviewed By:
All depletions monographs have been reviewed by a
team of experts including
Derrick M. DeSilva, Jr., MD, Raritan Bay Medical Center, Perth Amboy, NJ;
Jacqueline A. Hart, MD, Department of Internal Medicine, Newton-Wellesley
Hospital, Harvard University and Senior Medical Editor, A.D.A.M., Inc., Boston,
MA; John Hinze, PharmD, NMD, Woodbine, IA; Ruth Marlin, MD, Medical Director and
Director of Medical Education, Preventive Medicine Research Institute,
Sausalito, CA; Brian T Sanderoff, PD, BS in Pharmacy, Clinical Assistant
Professor, University of Maryland School of Pharmacy; President, Your
Prescription for Health, Owings Mills, MD; Leonard Wisneski, MD, FACP, George
Washington University, Rockville, MD; Ira Zunin, MD, MPH, MBA, President and
Chairman, Hawaii State Consortium for Integrative Medicine, Honolulu,
HI. | ||
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