If you are currently being treated with any of the following medications, you should not use manganese supplements without first talking to your healthcare provider.

Haloperidol and other Antipsychotics
There has been at least one report of an interaction between haloperidol and manganese that resulted in hallucinations and behavioral changes in a person with liver disease. In addition, some experts believe that medications for schizophrenia and other forms of psychosis may worsen side effects from manganese supplements. Therefore, individuals taking haloperidol or other antipsychotic medications (particularly a class called phenothiazines which includes chlorpromazine, mesoridazine, perphenazine, prochlorperazine, thioridazine, and trifluoperazine) should use manganese only under the careful supervision of a qualified health professional.

Reserpine
Reserpine, a medication used to treat high blood pressure, may decrease manganese levels in the body.